Bomedemstat vs Best Available Therapy for Essential Thrombocythemia

We are studying a new treatment for patients with essential thrombocythemia who haven't responded to hydroxyurea. The trial aims to see if bomedemstat is safer and more effective than current therapies.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anagrelide Hydrochloride Monohydrate
Anagrelide hydrochloride monohydrate is a substance that lowers abnormally high platelet counts to reduce the risk of clots.
Busulfan
Busulfan is a substance used to destroy bone marrow cells before a bone marrow transplant and to treat certain blood cancers.
Peginterferon Alfa-2a
Peginterferon Alfa-2a is a substance that stimulates the immune system to help treat chronic hepatitis C and other viral infections.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Bomedemstat
Mk-3543

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Ziekenhuis Aan De Stroom
Haematology
Antwerpen, Belgium
Centre Hospitalier Et Universitaire De Limoges
Clinical hematology and cell therapy
Isle, France
Centre Hospitalier Regional Universitaire De Tours
Hematology and cell therapy
La Riche, France

Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.