BRAF Alterations in Cancer: FORE8394 Treatment Study

We are testing the drug FORE8394 in patients with advanced solid tumors or specific brain tumors that have BRAF alterations. The goal is to see if it can effectively treat these cancers.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cobaxid
Tybost
Tybost is a medicine used to boost other HIV drugs' effectiveness by increasing their levels in the body.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cobamamide
Cobamamide is an active form of vitamin B12 used to correct B12 deficiency and support nerve function.
Cobicistat
Cobicistat is a substance that boosts levels of certain HIV treatments by slowing their breakdown in the body.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

N-[3-[5-(2-Cyclopropylpyrimidin-5-yl)-1H-Pyrrolo[2,3-b]pyridine-3-Carbonyl]-2,4-Difluorophenyl]-3-Fluoropyrrolidine-1-Sulfonamide

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

B12 Jaba
Cobaforte
Cobaxid Infantil

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut De Cancerologie De L Ouest
Service Oncologie Médicale
Angers, France
Institut Bergonie
Service Oncologie Médicale
Bordeaux, France
Centre Hospitalier Regional Et Universitaire De Brest
Service Pneumologie
Guilers, France

Sponsor: Fore Biotherapeutics Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.