BRAF V600E Mutated Metastatic Colorectal Cancer: ENCORAFENIB and FOLFIRI

We are studying a combination of ENCORAFENIB and FOLFIRI for patients with BRAF V600E mutated metastatic colorectal cancer that has progressed on previous treatments. The goal is to see if this combination can improve treatment outcomes and safety.

1-2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOralInjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Irinotecan
Irinotecan is a chemotherapy medicine used to treat certain cancers, especially colorectal cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cetuximab
Cetuximab is a substance that targets a protein on cancer cells to help slow or stop growth in colorectal and head and neck cancers.
Disodium Folinate
Disodium folinate is a form of folate used to prevent or treat folate deficiency and to protect healthy cells during certain cancer treatments.
Encorafenib
Encorafenib is a substance that targets cancer cells with a specific BRAF gene mutation to help slow tumor growth.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Campto
Canri
Chlorhydrate D'irinotécan Trihydraté Sun

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Oncologia Medica
La Massimina-Casal Lumbroso, Italy
Fondazione IRCCS Istituto Nazionale Dei Tumori
Oncologia Medica 1
Milan, Italy
Pia Fondazione Di Culto E Religione Card G Panico
Oncologia
Tricase, Italy
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.