Breast Cancer: Genomics Guided Therapy Study

We are exploring whether a personalized treatment approach after surgery can improve outcomes for patients with early high-risk breast cancer. This study will assess survival rates and the safety of the new therapy.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Herceptin
Herceptin is a medicine used to treat certain types of breast and stomach cancer.
Lynparza
Lynparza is a cancer medicine used to treat certain ovarian, breast, pancreatic, and prostate cancers, especially those caused by specific gene changes.
Phesgo
Phesgo is a medication used to treat HER2-positive breast cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Atezolizumab
Atezolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-L1.
Olaparib
Olaparib is a substance used to treat certain cancers by blocking a DNA-repair protein so cancer cells cannot fix damage and die.
Pertuzumab
Pertuzumab is a targeted antibody used to treat HER2-positive breast cancer by blocking signals that help tumor cells grow.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Inavolisib
Ipatasertib

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Herwenda
Herwenda
Herzuma

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Charite Universitaetsmedizin Berlin KöR
Klinik für Gynäkologie mit Brustzentrum
Berlin, Germany
Technische Universitaet Dresden
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
Dresden, Germany
Universitaetsklinikum Erlangen AöR
Frauenklinik
Erlangen, Germany

Sponsor: Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.