Breast Cancer: Nivolumab and Novel Immunotherapies

We are studying whether nivolumab, alone or with other treatments, can help achieve a complete response in early breast cancer patients before surgery. This trial also looks at safety and how well the treatment works.

≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesInjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Doxorubicine Hcl Hikma
Doxorubicine Hcl Hikma is a chemotherapy medicine used to treat several types of cancer.
Opdivo
Opdivo is a cancer medicine that helps the immune system find and fight tumor cells.
Paclitaxel Fresenius Kabi
Paclitaxel Fresenius Kabi is a chemotherapy medicine used to treat several types of cancer, including breast, ovarian, and lung cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cyclophosphamide
Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.
Doxorubicin Hydrochloride
Doxorubicin hydrochloride is a chemotherapy substance used to treat various cancers by killing or slowing the growth of cancer cells.
Ipilimumab
Ipilimumab is a substance that helps the immune system attack cancer by blocking a protein that keeps immune cells from working.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abutrax
Adriacept Blasen-Instillations-Set
Adriamycin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
MOD
Amstelveen, Netherlands
Sponsor: Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.