Breast Cancer: Palbociclib and Fulvestrant Study

We are investigating if a new treatment combination can help prevent relapse in patients with ER positive HER2 negative breast cancer. This study focuses on those with detectable tumor DNA during treatment.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Anastrozole
Anastrozole is a medicine used to treat certain breast cancers by reducing estrogen levels to help stop tumor growth.
Exemestane
Exemestane is a medicine used to lower estrogen and treat certain breast cancers in women who have gone through menopause.
Fulvestrant Eg
Fulvestrant Eg is a medicine used to treat advanced or metastatic breast cancer that depends on hormones.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anastrozole
Anastrozole is a substance that lowers estrogen levels to help treat and prevent hormone-sensitive breast cancer in postmenopausal women.
Exemestane
Exemestane is a substance that lowers estrogen levels to help treat hormone-sensitive breast cancer in postmenopausal women.
Fulvestrant
Fulvestrant blocks and destroys estrogen receptors to treat hormone receptor–positive breast cancer.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adifen 10mg
Adiunastrol
Afultrant

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut De Cancerologie De L Ouest
Oncologie Médicale
Angers, France
Centre Hospitalier Annecy Genevois
Cancérologie - Oncologie
Annecy, France
Institut De Cancerologie De L Ouest
Oncologie Médicale
Avignon, France

Sponsor: The Royal Marsden NHS Foundation Trust
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.