Breast Cancer: Patritumab Deruxtecan vs. Standard Treatment

We are studying a new medication for patients with hormone receptor-positive, HER2-negative advanced breast cancer. The goal is to see if it works better than the current treatment options.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Capecitabine
Capecitabine is a chemotherapy medicine used to treat certain cancers, including breast and colon cancer.
Paclitaxel
Paclitaxel is a chemotherapy medicine used to treat various types of cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Capecitabine
Capecitabine is a substance that helps stop certain cancers from growing, commonly used for breast and colorectal cancer.
Doxorubicin
Doxorubicin is a chemotherapy substance used to treat various cancers by killing rapidly dividing cancer cells.
Doxorubicin Hydrochloride
Doxorubicin hydrochloride is a chemotherapy substance used to treat various cancers by killing or slowing the growth of cancer cells.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Mk-1022
Liposomal
Patritumab Deruxtecan

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abutrax
Apexelsin
Axitaxel

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Regional Et Universitaire De Brest
Oncologie
Guilers, France
Centre Leon Berard
Oncologie
Meyzieu, France
Centre Henri Becquerel
Oncologie
Rouen, France

Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.