Breast Cancer Treatment: Elacestrant with Olaparib

We are studying whether adding elacestrant to the standard treatment olaparib helps women with hormone receptor-positive, HER2-negative breast cancer and gBRCA1/2 mutations. This trial aims to improve progression-free survival and overall treatment outcomes.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Elicea
Elicea is an antidepressant medicine used to treat depression and certain anxiety disorders.
Lynparza
Lynparza is a cancer medicine used to treat certain ovarian, breast, pancreatic, and prostate cancers, especially those caused by specific gene changes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Elacestrant
Elacestrant is a substance that blocks and reduces estrogen receptor activity to treat estrogen receptor–positive breast cancer.
Escitalopram
Escitalopram is a substance that helps improve mood and reduce anxiety in people with depression or anxiety disorders.
Olaparib
Olaparib is a substance used to treat certain cancers by blocking a DNA-repair protein so cancer cells cannot fix damage and die.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aciprex
Amasci
Apoescitaxin Oro

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Haematologie-Onkologie im Zentrum MVZ GmbH
Dres. Heinrich / Bangerter
Augsburg, Germany
Klinikum Bayreuth GmbH
Frauenklinik
Bayreuth, Germany
Praxisklinik Krebsheilkunde Fuer Frauen
Praxisklinik Krebsheilkunde
Berlin, Germany

Sponsor: GBG Forschungs GmbH
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.