Breast Cancer Treatment for Women 70+: Radiation vs. Hormone Therapy

We are comparing radiation therapy and hormone therapy for older women with early-stage luminal A-like breast cancer. The goal is to see which treatment better controls cancer and improves quality of life.

1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOralOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Anastrozole
Anastrozole is a medicine used to treat certain breast cancers by reducing estrogen levels to help stop tumor growth.
Exemestane
Exemestane is a medicine used to lower estrogen and treat certain breast cancers in women who have gone through menopause.
Letrozole
Letrozole is a medicine used to treat certain breast cancers in women after menopause by lowering hormones that can fuel tumor growth.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anastrozole
Anastrozole is a substance that lowers estrogen levels to help treat and prevent hormone-sensitive breast cancer in postmenopausal women.
Exemestane
Exemestane is a substance that lowers estrogen levels to help treat hormone-sensitive breast cancer in postmenopausal women.
Letrozole
Letrozole is a substance that lowers estrogen to treat certain types of breast cancer in postmenopausal women.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adifen 10mg
Adiunastrol
Agerdex

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Istituto Di Candiolo Fondazione Del Piemonte Per Loncologia IRCCS
Radioterapia Istituto di Candiolo
Airali, Italy
Azienda Ospedaliera Nazionale Ss Antonio E Biagio E C Arrigo Alessandria
S.C. di Radioterapia Oncologica
Alessandria, Italy
Centro Di Riferimento Oncologico Di Aviano
SOC Oncologia Radioterapica
Aviano-Castello, Italy
Sponsor: University Of Florence
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.