Brexucabtagene Autoleucel for Rare B-cell Malignancies

We are studying a new treatment for adults with relapsed or refractory Richter Transformation of B-cell malignancies. The goal is to see if it improves response rates and overall survival compared to existing options.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carboplatin
Carboplatin is a chemotherapy medicine used to treat various types of cancer.
Etoposide
Etoposide is a chemotherapy medicine used to treat various types of cancer.
Imbruvica
Imbruvica is a medicine used to treat certain types of blood cancers, including some forms of lymphoma and leukemia.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Alpelisib
Alpelisib is a substance that targets a cancer growth pathway to treat certain breast cancers with specific gene mutations.
Betamethasone Sodium Phosphate
Betamethasone sodium phosphate is a corticosteroid substance that reduces inflammation and suppresses immune reactions in allergic, inflammatory, and skin conditions.
Betamethasone Sodium Phosphate Ph. Eur
Betamethasone sodium phosphate is a substance that reduces inflammation and calms the immune system.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adelcort®
Alpicort
Alpicort E

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Vienna
Department of Medicine I, Division of Hematology, Hemostaseology
Vienna, Austria
Centre Hospitalier Regional Universitaire De Lille
Hopital Claude Huriez
Loos, France
Centre Hospitalier Lyon Sud
Service d'Hematologie Clinique
Oullins, France

Sponsor: Kite Pharma Inc.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.