Systemic Sclerosis
Systemic Sclerosis, commonly known as scleroderma, is a chronic autoimmune disease that causes the skin and connective tissues to become thick and hard, potentially affecting internal organs.
CAR-T Cell Therapy for Autoimmune Diseases
We are studying a new CAR-T cell treatment for patients with active autoimmune diseases like lupus, systemic sclerosis, and inflammatory myopathy. The trial aims to assess safety and how well this therapy works in reducing disease symptoms.
6-12 monthsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesInjectionDermatologyNeurologyRheumatology
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE) is an autoimmune disease where the body's immune system mistakenly attacks healthy tissue, leading to inflammation and damage in various parts of the body.
Idiopathic Inflammatory Myopathy
Idiopathic Inflammatory Myopathy refers to a group of diseases characterized by muscle inflammation and weakness, with no known cause, affecting mobility and daily activities.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you at least 18 years old?
- Are you currently pregnant or breastfeeding?
- Do you have severe kidney disease (eGFR ≤ 30 ml/min/m2) or severe liver disease (Child Pugh C)?
- Are you taking any medications that suppress your immune system, like prednisone or methotrexate?
- Have you had any major health issues like cancer or severe heart problems in the last 5 years?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Mb-Cart19.1
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Universitaetsklinikum Erlangen AöR
Department of Internal Medicine 3 - Rheumatology and Immunology
Erlangen, Germany
Sponsor: Miltenyi Biomedicine GmbH
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.