CAR-T-Cell Treatment for High-Risk Mantle Cell Lymphoma

We are exploring a new CAR-T-cell therapy for patients with untreated high-risk Mantle Cell Lymphoma. The study compares this new approach to the standard treatment to see which is more effective and safer.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Bendamustine
Bendamustine is a chemotherapy medicine used to treat certain blood cancers, such as lymphoma and some types of leukemia.
Carmustine
Carmustine is a chemotherapy medicine used to treat certain cancers, including some brain tumors and blood cancers.
Cytarabine

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bendamustine
Bendamustine is a substance used to treat certain cancers, especially non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Bendamustine Hydrochloride
Bendamustine hydrochloride is a chemotherapy substance used to treat certain blood cancers by killing cancer cells.
Brexucabtagene Autoleucel
Brexucabtagene autoleucel uses a patient’s engineered immune cells to target and help eliminate certain B‑cell blood cancers such as lymphoma and leukemia.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Accofil
Adelcort®
Alexan

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Fakultni Nemocnice Brno
Interní hematologická a onkologická klinika
Brno, Czechia
Vseobecna Fakultni Nemocnice V Praze
I. interní klinika - klinika hematologie
Prague, Czechia
Centre Hospitalier Universitaire De Bordeaux
Hematology
Canéjan, France

Sponsor: Klinikum Der Universitat Munchen AöR
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.