Cardiac Surgery: DOAC vs. Vitamin K Antagonist Study

We are studying the safety of two blood thinners for patients with atrial fibrillation after heart surgery. This research may help determine the best anticoagulation treatment for these patients.

>2 years Confirmation phase (III)No Placebo Standard Medicines OralCardiologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Apixaban

Apixaban is a medicine that helps prevent dangerous blood clots and reduces the risk of stroke in people with an irregular heart rhythm.

Edoxaban

Edoxaban is a medicine that thins the blood to help prevent strokes in people with irregular heartbeat and treat or prevent harmful blood clots.

Phenprocoumon Acis

Phenprocoumon Acis is a medicine used to prevent harmful blood clots in people at risk of stroke or other clot-related problems.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Apixaban

Apixaban is a substance that helps prevent harmful blood clots and lowers stroke risk in people with irregular heart rhythm.

Dabigatran

Dabigatran is a substance that helps prevent and treat blood clots by reducing the blood's ability to form clots.

Edoxaban

Edoxaban is a substance that helps prevent harmful blood clots and lowers stroke risk in people with an irregular heartbeat.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abatixent

Abidalo

Aboxoma

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Universitaetsklinikum Bonn AöR

Cardiac Surgery

Bonn, Germany

Universitaetsklinikum Essen AöR

Thoracic and Cardiovascular

Essen, Germany

Herzzentrum Leipzig GmbH

Cardiac Surgery

Großpösna, Germany

Sponsor: Hamilton Health Sciences Corporation

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.