Cardiac Surgery: Vasopressin vs. Norepinephrine

We are comparing two medications to see which better protects kidney function and reduces complications in patients at risk during cardiac surgery. This study aims to improve outcomes for those undergoing surgery with heart-lung machines.

>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesInjectionCardiologyInternal MedicineNephrologyOtolaryngology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Argipressin Aop
Argipressin Aop is a medicine used to raise blood pressure and reduce excessive urine output in certain medical conditions.
Noradrenaline Sans Conservateur Renaudin
Noradrenaline Sans Conservateur Renaudin is a medicine used to quickly raise very low blood pressure in emergency or intensive care situations.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Argipressin
Argipressin is a hormone-like substance that raises blood pressure by narrowing blood vessels and reduces severe bleeding.
Noradrenaline Hydrochloride
Noradrenaline hydrochloride is a substance that raises blood pressure by narrowing blood vessels and supporting heart function in severe low blood pressure or shock.
Noradrenaline Tartrate
Noradrenaline tartrate is a substance that raises blood pressure by constricting blood vessels and supporting heart function during severe low-blood-pressure situations.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Reverpleg

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Argipressin Farmak
Argipressin Mercury Pharmaceuticals Ltd
Argipressin Vantage

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire Amiens Picardie
Anesthésie- Réanimation
Amiens, France
Clinique De La Sauvegarde
Anesthésie-réanimation
Champagne-au-Mont-d'Or, France
Centre Hospitalier Universitaire De Montpellier
Anesthésie- Réanimation
Montpellier, France
Sponsor: Centre Hospitalier Universitaire Dijon Bourgogne
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.