Cardiogenic Shock: Beta Receptor Modulation Trial

We are testing a new approach to manage heart function in patients with cardiogenic shock on V-A ECMO. This study compares reducing beta receptor stimulation to the usual treatment to see which is safer and more effective.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Dobutamine Hameln
Dobutamine Hameln is a hospital medicine that helps a weak heart pump more strongly during severe heart failure or shock.
Esmolol Hcl Lyo Orpha
Esmolol Hcl Lyo Orpha is a fast-acting heart medicine used to quickly lower very fast heart rates and control blood pressure in urgent situations.
Milrinon Hikma
Milrinon Hikma is a medicine used to help the heart pump stronger and improve blood flow in people with severe heart failure.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dobutamine
Dobutamine is a substance that helps the heart contract more strongly to improve blood flow in acute heart failure or low cardiac output.
Esmolol Hydrochloride
Esmolol hydrochloride is a short-acting beta-blocker used to quickly slow fast heart rate and lower high blood pressure.
Milrinone
Milrinone is a substance that helps the heart pump stronger and relaxes blood vessels to improve blood flow in severe heart failure.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Asicor
Asicord
Brevibloc

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Intensive Care and Cardiology
Rotterdam, Netherlands
Sponsor: Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.