Obesity
Obesity is a medical condition defined by an excess of body fat, which can increase the risk of various health problems, including heart disease, diabetes, and certain cancers. It is often measured using the Body Mass Index (BMI).
Cardiovascular Safety: BI 456906 for Overweight Individuals
We are testing a new medication for people with overweight or obesity and cardiovascular disease to see if it is as safe as a placebo. The study will also look at its effects on blood pressure and waist size.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you at least 18 years old?
- Do you have a BMI of 27 or higher with heart problems or weight-related issues, or a BMI of 30 or higher with heart or kidney problems?
- Do you have Type 1 diabetes?
- Have you taken GLP-1R agonists like Ozempic or Trulicity in the last 3 months?
- Do you have any severe stomach problems that affect how food moves through your stomach?
What active substances are being studied?
Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.
Biotin
Biotin is a B vitamin that helps the body convert food into energy and supports healthy hair, skin, and nails.
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Bi 456906
Survodutide
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
Loading map...
University Hospital Graz
Clinical Department of Endocrinology and Diabetology
Graz, Austria
Medizinische Universitaet Innsbruck
Department of Internal Medicine I
Innsbruck, Austria
Konvent Der Barmherzigen Brueder
Departement for Internal Medicine
Linz, Austria
Gemeinnutzige Salzburger Landes kliniken Betriebsgesellschaft mbH
Internal University Clinic
Salzburg, Austria
Landesklinikum Stockerau
Medical Department
Stockerau, Austria
Allgemeines Krankenhaus Der Stadt Wien Universitatskliniken
Medical Department I, Diabetology, Endocrinology and Nephrology
Vienna, Austria
Klinik Landstrabe
Medical Department of Diabetology, Endocrinology and Nephrology
Vienna, Austria
Zentrum Fur Klinische Studien Dr. Hanusch GmbH
Private Practice
Vienna, Austria
UZ Leuven
Endocrinology
Heverlee, Belgium
Az St-Jan Brugge-Oostende A.V.
Endocrinology
Sint-Andries, Belgium
Antwerp University Hospital
Endocrinology
Wilrijk, Belgium
Medical Centre Synexus Sofia EOOD
Medical Center Synexus Sofia EOOD
Lozen, Bulgaria
Mbal Sveta Karidad EAD
Clinical trial center
Plovdiv, Bulgaria
Multi Profile Hospital For Active Treatment Trimontium OOD
Department of Internal Diseases
Plovdiv, Bulgaria
Diagnostichno-Konsultativen Centar-Sliven OOD
Department of Endocrinology and Obstruction Diseases
Sliven, Bulgaria
Alexandrovska University Hospital
Department of Endocrinology and Obstruction Diseases
Sofia, Bulgaria
Ambulatory of specialized outpatient medical help in internal diseases and cardiology Individual practice Cardio Tonus EOOD
ASOMHIDC - Individual practice "Cardio Tonus" EOOD
Sofia, Bulgaria
Diagnostic-Consultative Center Alexandrovska EOOD
clinical trial rooms
Sofia, Bulgaria
Uniteversity Muliprofile Hospital For Active Treatment Tsaritsa Yoanna-Isul EAD
Department of Cardiology
Sofia, Bulgaria
Diagnostic Consultative Centre Ascendent OOD
Diagnostic-Consultative Centre Ascendent - clinical trial rooms
Tutrakan, Bulgaria
Multiprofessional Hospital For Active Treatment Iulia Vrevska-Byala EOOD
Department of internal medicine
Tutrakan, Bulgaria
Multiprofile Hospital For Active Treatment Dobrich AD
1st Department of Internal Medicine
Tutrakan, Bulgaria
Multiprofile Hospital For Active Treatment St. Panteleimon Yambol AD
Cardiology, endocrinology and metabolic diseases
Tutrakan, Bulgaria
Multiprofile Hospital For Active Treatment Sveti Ivan Rilski 2003 OOD
Clinical Trial Center
Tutrakan, Bulgaria
Medical Center Berbatov Ltd.
Practice
Yambol, Bulgaria
Fakultni Nemocnice U Sv Anny V Brne
Diabetology ambulance
Brno, Czechia
Dum zdravi Havirov s.r.o.
Private practice
Havířov, Czechia
Fakultni Nemocnice Ostrava
Department of Cardiology and Internal Medicine
Hlučín, Czechia
Center for Osteoporosis Therapy
Private Practice
Karlovy Vary, Czechia
Diabetology Krnov
Private Practice
Krnov, Czechia
Interni a diabetologicka ordinace s.r.o.
Private Practice
Náchod, Czechia
PreventaMed s.r.o.
Practice
Olomouc, Czechia
Dialine s.r.o.
Private Practice
Pilsen, Czechia
Institute For Clinical And Experimental Medicine
Obesitology center
Prague, Czechia
OB klinika a.s.
Private Practice
Prague, Czechia
ResTrial s.r.o.
Private Practice
Prague, Czechia
Synexus Czech s.r.o.
Clinical Trials Center
Prague, Czechia
Vseobecna Fakultni Nemocnice V Praze
Obesitology center
Prague, Czechia
Aarhus University Hospital
Department of Cardiology
Århus, Denmark
Copenhagen University Hospital
Department of Cardiology
Copenhagen, Denmark
Regionshospitalet Godstrup
Klinik for Hjerteforskning
Herning, Denmark
Hvidovre Hospital
Department of Cardiology
Hvidovre, Denmark
Herlev Hospital
Hjertemedicinsk Forskning
Rødovre, Denmark
StudyCor Oy
Jyväskylä, Finland
Velocity Clinical Research GmBH
Velocity Clinical Research GmBH
Berlin, Germany
DRK Kliniken Berlin
Berliner Adipositaszentrum
Eichwalde, Germany
Universitatsklinikum Erlangen AöR
Medizinische Klinik 1
Erlangen, Germany
IKF Pneumologie GmbH & Co. KG
Institut für klinische Forschung Pneumologie
Frankfurt am Main, Germany
Synexus Clinical Research GmbH
Synexus Frankfurt Research Centre
Frankfurt am Main, Germany
Medical Center - University Of Freiburg
Klinik für Innere Medizin II
Freiburg, Germany
Centrum Fuer Diabetologie Und Allgemeinmedizin
Centrum für Diabetologie und Allgemeinmedizin
Gießen, Germany
St. Josefskrankenhaus Heidelberg GmbH
Klinisches Studienzentrum
Heidelberg, Germany
Universitaetsklinikum Schleswig-Holstein
Innere Medizin I mit Schwerpunkt Endokrinologie, Diabetologie und Klinische Ernährungsmedizin
Kiel, Germany
University Hospital Cologne AöR
Poliklinik für Endokrinologie, Diabetologie und Präventivmedizin (PEDP)
Köln, Germany
Medizinische Hochschule Hannover Service GmbH
Klinik für Gastroenterologie, Hepatologie, Endokrinologie
Laatzen, Germany
Synexus Clinical Research GmbH
Prüfzentrum Leipzig
Leipzig, Germany
Velocity Clinical Research Germany GmbH
Velocity Clinical Research Germany GmbH
Leipzig, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
1. Medizinische Klinik
Mainz, Germany
Westfaelische Wilhelms-Universitaet Muenster
Gastroenterologie; Hepatologie, Endokrinologie, Klinische Infektiologie
Münster, Germany
Synexus Clinical Research GmbH
Prüfzentrum Berlin
Neuenhagen, Germany
Universitaetsklinikum Tuebingen
Innere Medizin IV Klinik für Diabetologie, Endokrinologie, Nephrologie
Tübingen, Germany
Universitaetsklinikum Aachen AöR
Klinisches Studienzentrum, Medizinische Klinik I
Vaals, Germany
Athens Medical Center S.A.
Internal Medicine Clinic - Diabetic Center
Athens, Greece
Laiko General Hospital Of Athens
First Department of Propaedeutic Medicine, National and Kapodistrian University of Athens
Athens, Greece
University General Hospital Attikon
2nd Department of Internal Medicine, Research Unit and Diabetes Centre
Chaïdári, Greece
University General Hospital Of Ioannina
Department of Internal Medicine, University of Ioannina
Ioánnina, Greece
University General Hospital Of Ioannina
Department of Endocrinology, University of Ioannina
Ioánnina, Greece
University General Hospital Of Heraklion
Department of Internal Medicine, University of Crete
Irákleion, Greece
General University Hospital Of Larissa
Department of Endocrinology & Metabolic Diseases, University of Thessaly
Lárisa, Greece
Athens Medical Center S.A.
Diabetes Division
Palaió Fáliro, Greece
University General Hospital Of Thessaloniki Ahepa
First Department of Internal Medicine
Sykiés, Greece
Hippokration Hospital
Department of Endocrinology
Thessaloníki, Greece
Lausmed Kft.
Practice
Baja, Hungary
Budapesti Szent Ferenc Korhaz
Cardiology Rehabilitation Department
Budakeszi, Hungary
Central Hospital Of Northern Pest Military Hospital
Dep. II. Intern
Budapest, Hungary
Obudai Egeszsegugyi Centrum Kft.
Private Clinic
Budapest, Hungary
Semmelweis University
Heart and Vascular Center
Budapest, Hungary
SYNEXUS Magyarorszag Kft.
Private practice
Budapest, Hungary
Bajcsy-Zsilinszky Korhaz Es Rendelointezet
III. Internal Department
Csömör, Hungary
University Of Debrecen
Internal Medicine Clinic
Debrecen, Hungary
Studium Egeszseghaz Kft.
private clinic
Dömsöd, Hungary
Jahn Ferenc Del-Pesti Korhaz Es Rendelointezet
Dep. I. Intern and Cardiology
Dunaharaszti, Hungary
Erzsebet Gondozohaz Kft.
Private Practice
Gödöllő, Hungary
SYNEXUS Magyarorszag Kft.
Private Practice
Gyula, Hungary
Trial Pharma Kft.
Private practice
Gyula, Hungary
BKS Research Kft.
Private praxis
Hatvan, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz
Internal department
Kaposvár, Hungary
Obudai Egeszseguegyi Centrum Kft.
Private practice
Zalaegerszeg, Hungary
SYNEXUS Magyarorszag Kft.
Private Practice
Zalaegerszeg, Hungary
Connolly Hospital
Diabetes Centre
Blanchardstown, Ireland
University Hospital Galway
HRB Clinical Research Facility
Galway, Ireland
Cliniche Gavazzeni S.p.A.
Cardiologia
Bergamo, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
UOC Patologie dell'Obesità
La Massimina-Casal Lumbroso, Italy
Ospedale Santa Maria Goretti Latina
Dermatologia U
Latina, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
UOC di Endocrinologia e Malattie del Metabolismo
Palermo, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I
Scienze Endocrino-metaboliche e Malattie Infettive
Rome, Italy
Centro Cardiologico Monzino S.p.A.
diabetologia, endocrnologia e malattie metaboliche
San Donato Milanese, Italy
Fondazione Policlinico Universitario Campus Bio-Medico
endocrinologia e diabetologia
Selcetta, Italy
Multimedica S.p.A.
Dipartimento di Endocrinologia, Nutrizione e Malattie Metaboliche
Sesto San Giovanni, Italy
Azienda Ospedaliera Universitaria Senese
Diabetologia e malattie metaboliche
Siena, Italy
Rijnstate Ziekenhuis Stichting
Cardiology Department
Arnhem, Netherlands
Spaarne Gasthuis
Cardiology Department
Haarlem, Netherlands
Canisius Wilhelmina Hospital
Cardiology Department
Nijmegen, Netherlands
Diakonessenhuis Stichting
Cardiology Department
Utrecht, Netherlands
Maxima Medisch Centrum
Cardiology Department
Veldhoven, Netherlands
Vestre Viken HF
Avdeling for Atferdsmedisin
Drammen, Norway
Vestfold Hospital Trust
Hormon, overvekt og ernæringsavdelingen
Holmestrand, Norway
Helse Stavanger HF
Forskningsposten
Stavanger, Norway
Akershus University Hospital
Hjertemedisinsk avdeling
Strømmen, Norway
St. Olavs Hospital HF
Fedmepoliklinikken
Trondheim, Norway
Kresmed Sp. z o. o.
Private Practice
Białystok, Poland
Uniwersytecki Szpital Kliniczny W Bialymstoku
Clinical Department of Endocrinology, Diabetology & Int Dis
Białystok, Poland
Centrum Medyczne Intercor Sp. z o.o.
The Company of Doctors "Intercor" Ltd.
Bydgoszcz, Poland
Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j.
Private Practice
Bydgoszcz, Poland
Synexus Polska Sp. z o.o.
Private Practice
Częstochowa, Poland
Synexus Polska Sp. z o.o.
Private Practice
Gdynia, Poland
Niepubliczny Zaklad Opieki Zdrowotnej Euromedica Sp. z o.o.
Private practice
Grudziądz, Poland
Silmedic Sp. z o.o.
Private Practice
Katowice, Poland
Synexus Polska Sp. z o.o.
Private Practice
Katowice, Poland
Medyczne Centrum Diabetologiczno-Endokrynologiczno-Metaboliczne Diab-Endo-Met Sp. z o.o.
Private Practice
Kraków, Poland
Unicardia Specjalistyczne Centrum Leczenia Chorob Serca I Naczyn & Unimedica Specjalistyczne Centrum Medyczne & Uniestetica Centrum Chirurgii Plastycznej Rekonstrukcyjnej I Medycyny Estetycznej Malopolskie Kliniki Specjalistyczne Sp. z o.o.
Private Practice
Kraków, Poland
Centrum Medyczne Med-Gastr Sp. z o.o.
Private Practice
Łódź, Poland
Synexus Polska Sp. z o.o.
Private Practice
Łódź, Poland
Clinical Best Solutions Sp. z o.o. S.K.
Department of Cardiology and Intensive Coronary Care Unit
Lublin, Poland
Ekamed Sp. z o.o.
Private Practice
Lublin, Poland
Clinical Best Solutions Sp. z o.o. S.K.
Private Practice
Mokotów, Poland
NBR Poland Tomasz Klodawski
Private Practice
Mokotów, Poland
Etg Warszawa Sp. z o.o.
Private Practice
Ochota, Poland
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji
Department of Internal Medicine, Endocrinology and Diabetology
Ochota, Poland
Synexus Polska Sp. z o.o.
Private practice
Ochota, Poland
Futuremeds Sp. z o.o.
Practice
Olsztyn, Poland
Metabolic Health Center Pawel Bogdanski
Private Practice
Poznań, Poland
Private Practice Dr. Ewa Krzyzagorska
Private Practice
Poznań, Poland
Synexus Polska Sp. z o.o.
Private Practice
Poznań, Poland
Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu
Padre Pio Regional Hospital in Przemysl
Przemyśl, Poland
Synexus Polska Sp. z o.o.
Private Practice
Przymorze Małe, Poland
Centrum Medyczne Medyk Sp. z o.o.
Private Practice
Rzeszów, Poland
Velocity Skierniewice Sp. z o.o.
Private Practice
Skierniewice, Poland
NZOZ Procordis, Cardiology Research Center of Sopot
Dr. Pawel Miekus
Sopot, Poland
Velocity Nova Sp. z o.o.
Private Practice
Staszów, Poland
Dc-Med Sp. z o.o. S.K.
Private Practice
Świdnica, Poland
Salvia Lekston I Madej Sp. J.
Private Practice
Świętochłowice, Poland
Vita Longa Sp. z o.o.
Private Practice
Tychy, Poland
Synexus Polska Sp. z o.o.
Private Practice
Wrocław, Poland
Unidade Local De Saude Da Regiao De Aveiro E.P.E.
Serviço de Endocrinologia
Aveiro, Portugal
Unidade Local De Saude De Sao Jose E.P.E.
Serviço de Endocrinologia
Baixa, Portugal
Hospital Da Luz S.A.
Serviço de Endocrinologia
Benfica, Portugal
Galo Saude Parcerias Cascais S.A.
Serviço de Medicina Interna
Cascais, Portugal
Unidade Local De Saude De Entre O Douro E Vouga E.P.E.
Serviço de Medicina Interna
Feira, Portugal
CCAB Centro Clinico Academico Braga Associacao
Serviço de Endocrinologia
Gualtar, Portugal
Unidade Local De Saude Do Alto Ave E.P.E.
Serviço de Medicina Interna
Guimarães, Portugal
APDP Associacao Protectora Dos Diabeticos De Portugal
Departamento Estudos, Projetos e Ensaios Clínicos, Piso 4
Lisbon, Portugal
Hospital Da Luz Arrabida S.A.
Endocrinology, Diabetes and Obesity
Massarelos, Portugal
Cardiolima Centro Diagnostico Cardio-Pulmonar De Ponte De Lima Lda.
Serviço de Cardiologia
Ponte de Lima, Portugal
Ucardio Centro Clinico Unidade Cardiovascular
Serviço de Cardiologia
Riachos, Portugal
Unidade Local De Saude De Coimbra E.P.E.
Serviço de Cardiologia
Santo António dos Olivais, Portugal
Medispektrum s.r.o.
Private Practice
Bratislava, Slovakia
Metabol KLINIK s.r.o.
Practice
Bratislava, Slovakia
Human-Care s.r.o.
Practice
Košice, Slovakia
Medical group Kosice s.r.o.
Practice
Košice, Slovakia
IN DIA s.r.o.
Practice
Lučenec, Slovakia
Funkystuff s.r.o
Practice
Nové Zámky, Slovakia
Diab s.r.o.
Practice
Rožňava, Slovakia
Hospital General Universitario Dr. Balmis
Servicio de Endocrinología
Alicante, Spain
Hospital Universitario Clinico San Cecilio
Servicio de Endocrinología
Armilla, Spain
Hospital Universitario Infanta Cristina
Servicio de Medicina Interna
Badajoz, Spain
Hospital Universitario Basurto
Servicio de Endocrinología
Barakaldo, Spain
Centro Medico Teknon-Grupo Quironsalud
Servicio de Endocrinología
Barcelona, Spain
Hospital Universitari Vall D Hebron
Servicio de Endocrinología
Barcelona, Spain
Hospital Universitario La Paz
Servicio de Endocrinología
Chamartín, Spain
Hospital Universitario Ramon Y Cajal
Servicio de medicina interna
Colmenar Viejo, Spain
Hospital Clinic De Barcelona
Servicio de Endocrinología
El Altet, Spain
Hospital Universitari De Girona Doctor Josep Trueta
Servicio de Endocrinología
Girona, Spain
Hospital Universitario Virgen De La Victoria
Servicio de Endocrinología
Málaga, Spain
Hospital Universitario Quironsalud Madrid
Servicio de Endocrinología
Pozuelo de Alarcón, Spain
Hospital Quironsalud Infanta Luisa
Servicio de Endocrinología
Sanlúcar de Barrameda, Spain
Hospital Universitario Marques De Valdecilla
Servicio de Cardiología
Santander, Spain
Complexo Hospitalario Universitario De Santiago
Servicio de Endocrinología
Santiago de Compostela, Spain
Hospital Universitario Dr Peset Aleixandre
Servicio de Endocrinología
Sedaví, Spain
Sponsor: Boehringer Ingelheim International GmbH
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.