Castration-Resistant Prostate Cancer: Darolutamide with Radiation Therapy

We are studying whether adding stereotactic radiation therapy to darolutamide helps patients with castration-resistant prostate cancer and a few metastases live longer without disease progression. We will also evaluate the treatment's safety and impact on quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Degarelix Accord
Degarelix Accord is a medicine used to treat advanced prostate cancer by quickly lowering male hormone levels.
Goserelin Endomedica
Goserelin Endomedica is a medicine that lowers sex hormone levels to treat prostate cancer and some women's reproductive conditions like endometriosis.
Nubeqa
Nubeqa is a medicine used to treat prostate cancer that continues to grow despite hormone therapy before it has visibly spread.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Darolutamide
Darolutamide is a substance that blocks male hormones' effects to help treat prostate cancer.
Degarelix
Degarelix is a substance that rapidly lowers testosterone to help control advanced prostate cancer.
Goserelin
Goserelin is a substance that lowers sex hormone levels to treat hormone-sensitive cancers and conditions.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Bay 1841788

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Algonad
Firmagon
Golexin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Ziekenhuis Aan De Stroom
Oncology
Berchem, Belgium
CHU Helora
Oncology
Fayt-lez-Manage, Belgium
Cliniques Universitaires Saint-Luc
Oncology
Sint-Stevens-Woluwe, Belgium

Sponsor: Unicancer
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.