Childhood Leukemia: Inotuzumab Ozogamicin vs. ALLR3

We are studying whether Inotuzumab Ozogamicin works better than standard treatment for children with high-risk first relapse B-cell leukemia. The trial focuses on safety and long-term effectiveness in young patients.

6-12 months 6-10 visits Efficacy phase (II)No Placebo Cost Reimbursement Investigational Medicines Oral InjectionHematologyPediatrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Besponsa

Besponsa is a medicine used to treat certain relapsed or hard‑to‑treat acute lymphoblastic leukemia, a type of blood cancer.

Dexamethason Jenapharm

Dexamethason Jenapharm is a medicine that reduces swelling and eases allergic or immune reactions and other serious health problems.

Dexamethasone

Dexamethasone is a medicine that reduces inflammation and calms the immune system to treat allergies, swelling, and other inflammatory conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Crisantaspase

Crisantaspase is an enzyme that lowers levels of the amino acid asparagine to help treat acute lymphoblastic leukemia.

Dexamethasone

Dexamethasone is a steroid that reduces inflammation and suppresses the immune system to treat allergic, inflammatory, and autoimmune conditions.

Dexamethasone Ph. Eur.

Dexamethasone Ph. Eur. is a steroid that reduces inflammation and suppresses the immune response in various inflammatory and allergic conditions.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Vincristine

Oncaspar

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aacidexam

Aflavis

Amelinor

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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St. Anna Kinderspital GmbH

Hämatologische, Onkologische und Immunologische Abteilung

Vienna, Austria

UZ Leuven

Heverlee, Belgium

Universiteit Gent

Pediatric Hemato-Oncologogy & Stem Cell Transplant

Ledeberg, Belgium

Sponsor: Pfizer Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.