Cholangiocarcinoma: Chemo and Immunotherapy Study

We are exploring a combination of chemotherapy and immunotherapy for patients with locally advanced cholangiocarcinoma before surgery. The study aims to see if this approach can lower the risk of cancer returning after treatment.

1-2 years6-10 visitsEfficacy phase (II)No PlaceboPartially RemoteStandard MedicinesInjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cisplatino Pfizer
Cisplatino Pfizer is a chemotherapy medicine used to treat various types of cancer.
Gemcitabina Accord
Gemcitabina Accord is a chemotherapy medicine used to treat several types of cancer, including pancreatic, lung, and bladder cancers.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cisplatin
Cisplatin is a substance used in chemotherapy to kill or stop the growth of cancer cells.
Durvalumab
Durvalumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein tumors use to hide.
Gemcitabine
Gemcitabine is a substance that slows or stops cancer cell growth and is used to treat several cancers, including pancreatic and lung.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bendacitabin
Cisplatin
Cisplatin "ebewe"

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli
U.O.C. of Hepatobiliary Surgery and Liver Transplants
Piscinola, Italy
Azienda Ospedaliera Universitaria Federico II Di Napoli
Medical Oncology
Piscinola, Italy
San Camillo Forlanini Hospital
Medical Oncology
Rome, Italy
Sponsor: IRCCS Istituto Nazionale Tumori Fondazione Pascale
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.