Cholangiocarcinoma: Ivosidenib with Durvalumab and Gemcitabine/Cisplatin

We are studying a new treatment combination for patients with locally advanced or metastatic cholangiocarcinoma with an IDH1 mutation. The goal is to evaluate its safety and early effectiveness as a first-line therapy.

>2 years 16-20 visits Safety phase (I)Efficacy phase (II)Post-Trial Drug Access No Placebo Investigational Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cisplatin Hikma

Cisplatin Hikma is a chemotherapy medicine used to treat various types of cancer.

Gemcitabin Hikma

Gemcitabin Hikma is a chemotherapy medicine used to treat several types of cancer.

Imfinzi

Imfinzi is a cancer medicine that helps the immune system find and fight tumor cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cisplatin

Cisplatin is a substance used in chemotherapy to kill or stop the growth of cancer cells.

Durvalumab

Durvalumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein tumors use to hide.

Gemcitabine

Gemcitabine is a substance that slows or stops cancer cell growth and is used to treat several cancers, including pancreatic and lung.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Ag-120/S95031

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bendacitabin

Cisplatin

Cisplatin "ebewe"

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...

Institut Bergonie

Gastroenlorology and Digestive Oncology

Bordeaux, France

Hopital Beaujon

Liver Cancer Unit and Therapeutic Innovation

Clichy, France

Centre Hospitalier Universitaire De Montpellier

Oncologie Médicale

Montpellier, France

Sponsor: Institut De Recherches Internationales Servier IRIS

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.