Cholangiocarcinoma: Tinengotinib Study

We are studying the safety and effectiveness of a new oral medication, tinengotinib, for patients with FGFR-altered cholangiocarcinoma that hasn't responded to other treatments. This trial compares tinengotinib to the physician's choice of treatment.

6-12 months Confirmation phase (III)No Placebo Partially Remote Investigational Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Benda-5 Fu

Bendafolin

Irinotecan Hcl Aqvida

Irinotecan Hcl Aqvida is a chemotherapy medicine used to treat certain cancers, most commonly advanced colorectal (bowel) cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Fluorouracil

Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.

Folinic Acid

Folinic acid is a substance that helps restore folate levels and protects healthy cells during certain chemotherapy treatments.

Irinotecan

Irinotecan is a chemotherapy substance used to treat certain cancers by blocking cancer cells from dividing and growing.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Tinengotinib

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

5-Fluorouracil

5-Fluorouracil Ebewe

5-Fluorouracil Sandoz

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Ordensklinikum Linz GmbH

Department of Internal Medicine I; Division of Medical Oncology and Haematology

Linz, Austria

Noe LGA Gesundheit Thermenregion GmbH

Division of Internal Medicine, Haematology and Internal Oncology

Wiener Neustadt, Austria

UZ Leuven

Digestive Oncology

Heverlee, Belgium

Sponsor: Transthera Sciences (Nanjing) Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.