Cholestatic Pruritus
Cholestatic pruritus is a condition characterized by intense itching due to the accumulation of bile salts in the bloodstream, often associated with liver diseases.
Cholestatic Pruritus: Linerixibat Treatment Study
We are studying the long-term safety and tolerability of linerixibat for people with cholestatic pruritus due to primary biliary cholangitis. The trial also looks at how this treatment affects quality of life and itch relief.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a chronic disease that slowly destroys the bile ducts in the liver, leading to cholestasis and potential liver damage.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 18 and 80 years old?
- Are you currently pregnant or breastfeeding?
- Do you have any liver disease, such as cirrhosis or severe liver problems?
- Are you taking Obeticholic acid or any other IBAT inhibitor?
- Do you have any current malignancies (cancers)?
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Universitair Ziekenhuis Gent
Hepatology and Gastroenterology
Ledeberg, Belgium
Hopital Erasme
Gastroenterology/Hepagestive Oncology
Negenmanneke, Belgium
Diagnostic Consultation Center XX-Sofia EOOD
Sofia, Bulgaria
Sponsor: Glaxosmithkline Research & Development Limited
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.