Primary Biliary Cholangitis
Primary Biliary Cholangitis (PBC) is a chronic autoimmune disease that slowly damages the bile ducts in the liver, leading to cholestasis and symptoms like itching, fatigue, and jaundice.
Cholestatic Pruritus: Volixibat Study
We are testing a new drug, volixibat, for patients with itching caused by primary biliary cholangitis. The study aims to see if it can reduce itching and improve quality of life compared to a placebo.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you 18 years old or older?
- Do you have a confirmed diagnosis of Primary Biliary Cholangitis (PBC)?
- Do you have chronic itching (pruritus) that is related to your PBC?
- Do you have any other liver diseases?
- Have you had any serious liver problems like variceal bleeding or ascites?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Volixibat
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Universitair Ziekenhuis Gent
Department of Gastroenterology and Hepatology
Ledeberg, Belgium
Cliniques Universitaires Saint-Luc
Hepatogastroenterology
Sint-Stevens-Woluwe, Belgium
Antwerp University Hospital
Gastroenterology & Hepatology
Wilrijk, Belgium
Sponsor: Mirum Pharmaceuticals Inc.
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.