Chronic Cluster Headache: Botulinum Toxin Treatment Study

We are investigating whether botulinum toxin can help people with chronic cluster headaches that haven't responded to other treatments. The study will also look at safety and how it affects headache frequency and quality of life.

3-6 months≤5 visitsConfirmation phase (III)Partially RemoteStandard MedicinesInjectionNeurology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Botox
Botox is a medicine used to relax muscles to reduce facial wrinkles and treat certain muscle- and nerve-related conditions.
Natriumklorid B. Braun
Natriumklorid B. Braun is a sterile saline solution used to replace body fluids and salts, hydrate patients, and flush wounds or medical lines.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Botulinum Antitoxin Type A Ph. Eur.
Botulinum antitoxin type A is a substance that neutralizes botulinum toxin to treat and prevent worsening paralysis caused by botulism.
Botulinum Toxin Type A
Botulinum toxin type A is a substance that temporarily relaxes muscles to reduce wrinkles and treat muscle overactivity.
Botulinum Toxin Type A - Haemagglutinin Complex
Botulinum toxin type A with haemagglutinin complex temporarily relaxes muscles by blocking nerve signals to treat muscle spasms and reduce wrinkles.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens
Addex Natriumklorid
Alluzience

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Praxisklinik Ulmenhof
Oral- and maxillofacial surgery
Hamburg, Germany
Norwegian University Of Science And Technolology
Neurology
Trondheim, Norway
St. Olavs Hospital HF
Neurology
Trondheim, Norway
Sponsor: Norwegian University Of Science And Technolology
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.