Chronic Graft-Versus-Host Disease: Axatilimab and Ruxolitinib Study

We are studying a new treatment combining axatilimab and ruxolitinib for people newly diagnosed with chronic graft-versus-host disease. The goal is to see if this combination is safe and effective in improving their condition.

>2 years >20 visits Efficacy phase (II)Post-Trial Drug Access No Placebo Cost Reimbursement Investigational Medicines Oral InjectionAllergologyHematologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Jakavi

Jakavi is a medicine used to treat certain serious blood disorders that affect bone marrow and blood cell production.

Prednisone Eg

Prednisone Eg is a steroid medicine that reduces inflammation and treats allergic, autoimmune, and other inflammatory conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Methylprednisolone

Methylprednisolone is a corticosteroid that reduces inflammation and calms an overactive immune system.

Prednisone

Prednisone is a steroid substance that reduces inflammation and suppresses the immune system for conditions like allergies, asthma, and autoimmune disorders.

Ruxolitinib

Ruxolitinib is a substance that blocks cell signals to reduce abnormal blood cell growth and inflammation in certain bone marrow disorders.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Axatilimab

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Brucorten

Cison

Cortancyl

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Jessa Ziekenhuis

Hematology

Hasselt, Belgium

UZ Leuven

Hematology

Heverlee, Belgium

UZ Leuven

Paediatric Haematology-Oncology and Stem Cell Transplantation

Heverlee, Belgium

Sponsor: Incyte Corp.

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.