Chronic HDV Infection: Tobevibart and Elebsiran Study

We are studying a new combination therapy for people with chronic HDV infection who haven't responded to prior treatment. The goal is to see if this therapy can effectively reduce the virus and improve liver health.

>2 years Confirmation phase (III)Post-Trial Drug Access No Placebo Cost Reimbursement Investigational Medicines InjectionHepatologyInfectious Diseases

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Hepcludex

Hepcludex is a medicine used to treat chronic hepatitis D, a viral infection of the liver.

Tobral

Tobral is an antibiotic eye medicine used to treat bacterial eye infections, like pink eye.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bulevirtide

Bulevirtide is a substance that prevents hepatitis B and D viruses from entering liver cells to help manage chronic hepatitis D.

Tobramycin

Tobramycin is an antibiotic substance used to treat serious bacterial infections, especially those affecting the lungs and eyes.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Vir-3434

Vir-2218

Elebsiran

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bradexa

Bramicil

Bramitob

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medizinische Universitaet Innsbruck

Universitätsklinik für Innere Medizin I

Innsbruck, Austria

Medical University Of Vienna

Universitätsklinik für Innere Medizin III, Klinische Abteilung für Gastroenterologie und Hepatologie

Vienna, Austria

Hospices Civils De Lyon

Hepatogastroenterology

Caluire-et-Cuire, France

Sponsor: Vir Biotechnology Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.