Chronic Heart Failure: Combined Diuretic Therapy Study

We are comparing a new combined diuretic treatment to standard therapies for people with chronic heart failure. The goal is to see if it improves exercise capacity and fluid management.

>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOralCardiologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Diamox
Diamox is a medicine used to prevent and treat altitude sickness and to lower eye pressure in glaucoma.
Zaroxolyn
Zaroxolyn is a medicine that helps the body remove excess water and salt to reduce swelling and lower blood pressure.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Acetazolamide
Acetazolamide is a substance that reduces fluid retention and lowers eye pressure, often used for glaucoma and to prevent altitude sickness.
Acetazolamide Sodium
Acetazolamide sodium is a substance that helps remove excess fluid and lowers eye pressure, commonly used for glaucoma and to prevent altitude sickness.
Metolazone
Metolazone is a substance that helps reduce excess fluid and lower blood pressure by increasing urine output.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acemit
Acetazolamid Agepha
Acetazolamida Arena

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centro Cardiologico Monzino S.p.A.
Heart Failure and Clinical Cardiology
San Donato Milanese, Italy
Sponsor: Centro Cardiologico Monzino S.p.A.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.