Chronic Lymphocytic Leukemia: Acalabrutinib vs. Venetoclax

We are comparing two treatment combinations for newly diagnosed chronic lymphocytic leukemia patients to see which is more effective and safer. We will also look at how these treatments affect patients' quality of life.

>2 years Confirmation phase (III)No Placebo Standard Medicines Oral InjectionHematologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Calquence

Calquence is a cancer medicine used to treat certain blood cancers, such as chronic lymphocytic leukemia and mantle cell lymphoma.

Gazyvaro

Gazyvaro is a cancer medicine used to treat certain blood cancers, including some types of lymphoma and chronic lymphocytic leukemia.

Venclyxto

Venclyxto is a medicine used to treat certain types of blood cancer, including some forms of leukemia and lymphoma.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Acalabrutinib

Acalabrutinib is a substance that blocks a protein in B cells to treat certain B‑cell blood cancers.

Obinutuzumab

Obinutuzumab is a lab-made antibody that targets and helps eliminate B cells to treat certain blood cancers like chronic lymphocytic and follicular lymphoma.

Venetoclax

Venetoclax is a substance used to treat certain blood cancers by helping cancer cells die.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Uniwersytecki Szpital Kliniczny w Białymstoku

Klinika Hematologii, Chorób Wewnętrznych i Angiologii z Pododdziałem Transplantacji Komórek Krwiotwó

Białystok, Poland

Wojewodzki Szpital Specjalistyczny W Legnicy

Oddział Hematologiczny

Legnica, Poland

Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii (WWCOiT) im. M. Kopernika w Łodzi

Oddział Hematologii Ogólnej i Chorób Wewnętrznych

Łódź, Poland

Sponsor: Specjalistyczny Szpital Im. Dra Alfreda Sokolowskiego

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.