Chronic Lymphocytic Leukemia: APG-2575 Study

We are studying a new medication, APG-2575, for patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. The trial will evaluate its safety and effectiveness alone and with other treatments.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Brukinsa
Brukinsa is a cancer medicine used to treat certain types of blood cancer, including mantle cell lymphoma and Waldenström’s macroglobulinemia.
Calquence
Calquence is a cancer medicine used to treat certain blood cancers, such as chronic lymphocytic leukemia and mantle cell lymphoma.
Imbruvica
Imbruvica is a medicine used to treat certain types of blood cancers, including some forms of lymphoma and leukemia.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Acalabrutinib
Acalabrutinib is a substance that blocks a protein in B cells to treat certain B‑cell blood cancers.
Ibrutinib
Ibrutinib is a substance that targets immune cell signaling to treat certain blood cancers, such as chronic lymphocytic leukemia and mantle cell lymphoma.
Rituximab
Rituximab is a substance that targets and reduces B cells, a type of white blood cell, to treat some blood cancers and autoimmune conditions.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Lisaftoclax

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Blitzima
Ituxredi
Rixathon

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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University Of Debrecen
Belgyógyászati Klinika, Hematológiai Tanszék
Debrecen, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz
Hematológiai Osztály
Kaposvár, Hungary
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz
Haematológiai Osztály
Nyíregyháza, Hungary

Sponsor: Ascentage Pharma Group Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.