Chronic Lymphocytic Leukemia: Lisaftoclax and Acalabrutinib Study

We are testing a new drug combination for patients newly diagnosed with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma. The study aims to see if this combination improves survival without disease progression compared to standard treatments.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Chlorambucil Aspen
Chlorambucil Aspen is a chemotherapy medicine used to treat certain types of cancer, especially some blood cancers like chronic lymphocytic leukemia.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Acalabrutinib
Acalabrutinib is a substance that blocks a protein in B cells to treat certain B‑cell blood cancers.
Chlorambucil
Chlorambucil is a chemotherapy substance used to treat certain blood cancers by slowing or stopping cancer cell growth.
Cyclophosphamide Monohydrate
Cyclophosphamide monohydrate is an anti-cancer substance used to treat various cancers and some serious autoimmune diseases.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Lisaftoclax

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Chloraminophene
Clorambucilo Aspen
Leukeran

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Umbal - Prof. D-R Stoyan Kirkovich AD
Department of clinical hematology
Kardzhali, Bulgaria
University Multiprofile Hospital For Active Treatment Dr. Georgi Stranski EAD
Clinic of clinical hematology
Pleven, Bulgaria
Specialized Hospital For Active Treatment Of Hematological Diseases EAD
First department of clinical hematology at Clinic of clinical hematology
Sofia, Bulgaria

Sponsor: Ascentage Pharma Group Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.