Chronic Lymphocytic Leukemia: Lisaftoclax Treatment Study

We are studying whether a new drug, lisaftoclax, combined with another treatment, helps patients with chronic lymphocytic leukemia who have been previously treated. The goal is to see if this combination improves survival and slows disease progression.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Brukinsa
Brukinsa is a cancer medicine used to treat certain types of blood cancer, including mantle cell lymphoma and Waldenström’s macroglobulinemia.
Calquence
Calquence is a cancer medicine used to treat certain blood cancers, such as chronic lymphocytic leukemia and mantle cell lymphoma.
Imbruvica
Imbruvica is a medicine used to treat certain types of blood cancers, including some forms of lymphoma and leukemia.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Acalabrutinib
Acalabrutinib is a substance that blocks a protein in B cells to treat certain B‑cell blood cancers.
Ibrutinib
Ibrutinib is a substance that targets immune cell signaling to treat certain blood cancers, such as chronic lymphocytic leukemia and mantle cell lymphoma.
Zanubrutinib
Zanubrutinib is a substance that treats certain B‑cell blood cancers by blocking a protein that helps cancerous B cells grow.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Lisaftoclax

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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CHU Helora
Hematology
Fayt-lez-Manage, Belgium
UZ Leuven
Hematology
Heverlee, Belgium
Universitair Ziekenhuis Gent
Hematology
Ledeberg, Belgium

Sponsor: Ascentage Pharma Group Inc.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.