Chronic Lymphocytic Leukemia: Tailored Ibrutinib Treatment

We are studying how personalized dosing of ibrutinib can improve treatment for patients with previously untreated chronic lymphocytic leukemia. The goal is to see if adjusting the dose based on side effects leads to better outcomes.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Imbruvica
Imbruvica is a medicine used to treat certain types of blood cancers, including some forms of lymphoma and leukemia.
Venclyxto
Venclyxto is a medicine used to treat certain types of blood cancer, including some forms of leukemia and lymphoma.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Ibrutinib
Ibrutinib is a substance that targets immune cell signaling to treat certain blood cancers, such as chronic lymphocytic leukemia and mantle cell lymphoma.
Venetoclax
Venetoclax is a substance used to treat certain blood cancers by helping cancer cells die.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Jnj-54179060

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Fakultni Nemocnice Brno
Interní hematologická a onkologická klinika
Brno, Czechia
Fakultni Nemocnice Ostrava
Klinika hematoonkologie
Hlučín, Czechia
Fakultni Nemocnice Hradec Kralove
IV. interní hematologická klinika
Hradec Králové, Czechia

Sponsor: Janssen - Cilag International
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.