Chronic Migraine: CGRP Monoclonal Antibody and Botox Combination Therapy

We are investigating whether a combination of CGRP monoclonal antibodies and Botox can reduce the number of migraine days for adults with chronic migraines. This study compares the effects of this dual therapy to a single treatment with CGRP monoclonal antibodies.

3-6 months6-10 visitsConfirmation phase (III)Partially RemoteStandard MedicinesInjectionInternal MedicineNeurology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Aimovig
Aimovig is a medicine used to prevent migraine headaches.
Ajovy
Ajovy is a medicine used to prevent migraine headaches in adults.
Botox
Botox is a medicine used to relax muscles to reduce facial wrinkles and treat certain muscle- and nerve-related conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Botulinum Antitoxin Type A Ph. Eur.
Botulinum antitoxin type A is a substance that neutralizes botulinum toxin to treat and prevent worsening paralysis caused by botulism.
Botulinum Toxin Type A
Botulinum toxin type A is a substance that temporarily relaxes muscles to reduce wrinkles and treat muscle overactivity.
Botulinum Toxin Type A - Haemagglutinin Complex
Botulinum toxin type A with haemagglutinin complex temporarily relaxes muscles by blocking nerve signals to treat muscle spasms and reduce wrinkles.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens
Addex Natriumklorid
Alluzience

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Helse Bergen HF
Neurology
Bergen, Norway
Sykehuset Innlandet HF
Neurology
Brumunddal, Norway
Sorlandet Sykehus HF
Neurology
Kristiansand, Norway
Sponsor: Oslo University Hospital HF
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.