Chronic Pouchitis in Children: Vedolizumab IV Study

We are testing the intravenous medication vedolizumab in children with active chronic pouchitis to see if it helps them achieve remission. The study will also look at how well the treatment is tolerated and its overall effectiveness.

1-2 years16-20 visitsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboCost ReimbursementStandard MedicinesOralInjectionGastroenterologyPediatrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Entyvio
Entyvio is a medicine used to treat moderate to severe ulcerative colitis and Crohn’s disease by reducing inflammation in the gut.
Rifaxan
Rifaxan is an antibiotic used to treat certain gut infections, including traveler’s diarrhea, and to help manage some bowel conditions.
Vedolix

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Amoxicillin
Amoxicillin is an antibiotic substance used to treat a range of common bacterial infections such as ear, throat, and urinary tract infections.
Amoxicillin Sodium
Amoxicillin Sodium is an antibiotic substance used to treat common bacterial infections.
Ciprofloxacin
Ciprofloxacin is an antibiotic used to treat various bacterial infections, such as urinary, respiratory, and skin infections.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

200 Mg + 500 Mg
3 Months Ibuprofen Strawberry Flavour
3 Months Plus Strawberry Flavour

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
UZ Leuven
Pediatrics
Heverlee, Belgium
Klinika Za Djecje Bolesti Zagreb
Children´s Hospital Zagreb
Zagreb, Croatia
Fakultni Nemocnice V Motole
Pediatrická klinika
Stodůlky, Czechia
Sponsor: Takeda Development Center Americas Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.