Colorectal Cancer: Flu Vaccine and Pembrolizumab Study

We are exploring whether a flu vaccine combined with pembrolizumab can help shrink tumors in patients with early pMMR colorectal cancer. The study will also assess safety and immune responses.

>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Influvac Tetra
Influvac Tetra is a vaccine that helps protect people each year against several common strains of seasonal flu.
Influvactetra
Influvactetra is a vaccine used to protect people from seasonal flu by preventing infection from four common influenza strains.
Keytruda
Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

A/Victoria/2570/2019 (H1n1)pdm09-Like Strain (A/Victoria/2570/2019, Ivr-215)
A/Victoria/2570/2019 (H1N1)pdm09-like strain is an influenza strain used in vaccines to stimulate immunity against H1N1 seasonal flu.
A/Victoria/4897/2022 (H1n1)pdm09-Like Strain (A/Victoria/4897/2022, Ivr-238)
A/Victoria/4897/2022 (H1N1)pdm09-like strain is an influenza A virus used in vaccines to help protect against H1N1 seasonal flu.
B/Phuket/3073/2013-Like Virus (B/Phuket/3073/2013, Wild Type)
B/Phuket/3073/2013-like virus is an influenza B strain used as a vaccine component to help protect people against seasonal flu.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Afluria Tetra
Afluria Tetra
Alpharix

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Zealand University Hospital
Department of Surgery
Køge, Denmark
Zealand University Hospital
Department of Oncology
Roskilde, Denmark
Slagelse Hospital
Department of Surgery
Slagelse, Denmark
Sponsor: Zealand University Hospital
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.