Metastatic Colorectal Cancer
Metastatic colorectal cancer is a stage of cancer where the disease has spread from the colon or rectum to other parts of the body. This often leads to more severe symptoms and requires advanced treatment options.
Colorectal Cancer: MK-1084 Treatment Study
We are testing a new treatment combining MK-1084, cetuximab, and chemotherapy for patients with advanced colorectal cancer. The goal is to see if this combination is safer and more effective than standard treatments.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
KRAS Mutation
A KRAS mutation refers to changes in the KRAS gene, which can lead to uncontrolled cell growth and is often associated with certain types of cancer, including colorectal cancer. This mutation can affect treatment options and prognosis.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 18 and 75 years old?
- Do you have colorectal cancer that is locally advanced or has spread (Stage III or IV)?
- Have you had major surgery in the past 3 months?
- Are you currently taking any medications for HIV, and is your HIV well controlled?
- Do you have any heart or blood vessel problems that are not under control?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Mk-1084
What similar medicines might you know?
Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.
Antrex
Buateron
Calcifolin
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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HUS-Yhtymae
HUS, Comprehensive Cancer Center
Helsinki, Finland
Tampere University Hospital
FONK
Tampere, Finland
Institut De Cancerologie De L Ouest
Oncologie
Angers, France
Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.