Colorectal Cancer: New Immunotherapy Treatment

We are studying a combination of Pembrolizumab and a Dendritic Cell Vaccine, followed by other medications, for patients with advanced colorectal cancer that hasn't responded to prior treatments. The goal is to see if this approach improves survival and safety.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Bcg Vaccine Ajv
Bcg Vaccine Ajv is a vaccine used to help prevent severe forms of tuberculosis, especially in infants and young children.
Keytruda
Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.
Lonsurf
Lonsurf is a cancer medicine used to treat advanced colorectal and stomach cancers when other treatments have failed.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bevacizumab
Bevacizumab is a substance that blocks formation of new blood vessels to treat certain cancers and eye conditions caused by abnormal vessel growth.
Danish Strain 1331
Mycobacterium Bovis
Mycobacterium bovis is a bacterium used in vaccines to prevent tuberculosis and to stimulate the immune system against some bladder cancers.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Vegzelma
Autologous Tumor Lysate-Loaded Dendritic Cells

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bcg Szczepionka Ajvaccines
Bcg Vaccin Ajv
Bcg Vaccine "aj Vaccines"

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l.
Medical Oncology
Meldola, Italy
Pia Fondazione Di Culto E Religione Card G Panico
Oncology and Palliative Care
Tricase, Italy
Sponsor: Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.