Colorectal Cancer: Post-Surgery Chemotherapy Study

We are investigating whether restarting chemotherapy after surgery helps patients with colorectal cancer that has spread to the liver live longer and stay cancer-free. This study compares different treatment approaches to find the best option.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate helps protect the body from side effects of some chemotherapy drugs and restores folate (vitamin B9) levels.
Irinotecan
Irinotecan is a chemotherapy medicine used to treat certain cancers, especially colorectal cancer.
Ondansetron
Ondansetron is a medicine that helps prevent nausea and vomiting after surgery or during cancer treatment.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.
Calcium Levofolinate
Calcium levofolinate is a substance that helps protect healthy cells during some cancer treatments and restores folate levels.
Fluorouracil
Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Antrex
Atossa
Avessaron

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut Bergonie
oncologie digestive
Bordeaux, France
Hopital De La Croix Rousse
chirugie Digestive et Générale
Caluire-et-Cuire, France
Centre Hospitalier Universitaire Amiens Picardie
Chirurgie Digestive
Colomiers, France

Sponsor: Assistance Publique Hopitaux De Paris
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.