Colorectal Liver Metastases: HAIP-SYST Treatment Study

We are investigating a new combination of local and systemic chemotherapy for patients with initially unresectable colorectal liver metastases. The study aims to see if this approach improves survival and quality of life compared to standard treatment.

1-2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesOralInjectionHepatologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate helps protect the body from side effects of some chemotherapy drugs and restores folate (vitamin B9) levels.
Capecitabine
Capecitabine is a chemotherapy medicine used to treat certain cancers, including breast and colon cancer.
Heparin
Heparin is a medicine used to prevent and treat blood clots.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bevacizumab
Bevacizumab is a substance that blocks formation of new blood vessels to treat certain cancers and eye conditions caused by abnormal vessel growth.
Calcium Folinate
Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.
Capecitabine
Capecitabine is a substance that helps stop certain cancers from growing, commonly used for breast and colorectal cancer.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Floxuridine

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aescin
Allé
Alle Forte

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Jeroen Bosch Ziekenhuis
Medical oncology
's-Hertogenbosch, Netherlands
Amsterdam UMC Stichting
Medical oncology
Amstelveen, Netherlands
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Surgery
Amstelveen, Netherlands
Sponsor: Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.