Combination Therapies for Advanced Esophageal Cancer

We are studying new treatment combinations for patients with advanced esophageal cancer who have already been treated with PD-1/PD-L1 therapies. The aim is to evaluate their safety and how well they work in shrinking tumors and improving survival.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Irinotecan
Irinotecan is a chemotherapy medicine used to treat certain cancers, especially colorectal cancer.
Keytruda
Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.
Lenvima
Lenvima is a cancer medicine used to treat certain types of thyroid, liver, and kidney cancers.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Buclizine Hydrochloride
Buclizine hydrochloride is an antihistamine substance used to prevent nausea, vomiting, and motion sickness.
Codeine Phosphate
Codeine phosphate is a substance that relieves mild to moderate pain and helps suppress coughing.
Famotidine
Famotidine is a substance that reduces stomach acid to relieve heartburn, acid reflux, and stomach ulcers.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Mk-2870
Mk-4830

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

4-In-One Flu Relief
6 Years Plus Paracetamol Boots
Abacat

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie)
Dresden, Germany
Haematologisch Onkologische Praxis Eppendorf
Hamburg, Germany
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l.
Oncologia Medica
Meldola, Italy

Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.