Crohn's Disease: Upadacitinib for Children

We are studying the effects of Upadacitinib in children with active Crohn's disease who haven't had success with other treatments. The goal is to see if it helps them achieve better health outcomes.

>2 years 11-15 visits Confirmation phase (III)Post-Trial Drug Access Cost Reimbursement Partially Remote Standard Medicines Oral InjectionGastroenterologyPediatrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Ciprofloxacin

Ciprofloxacin is an antibiotic used to treat various bacterial infections, such as urinary, respiratory, and skin infections.

Dexamethasone

Dexamethasone is a steroid that reduces inflammation and suppresses the immune system to treat allergic, inflammatory, and autoimmune conditions.

Methotrexate

Methotrexate is a substance that slows rapid cell growth and calms the immune system to treat certain cancers and autoimmune conditions.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Leuven

Gastro Enterology

Heverlee, Belgium

Association Hospitaliere De Bruxelles Hopital Universitaire Des Enfants Reine Fabiola

Gastro Enterology

Jette, Belgium

Centre Hospitalier Regional De La Citadelle

Gastro Enterology

Liège, Belgium

Sponsor: AbbVie Deutschland GmbH & Co. KG

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.