Cushing's Disease
Cushing's disease is a rare endocrine disorder caused by an overproduction of cortisol, often due to a tumor in the pituitary gland. Symptoms may include weight gain, high blood pressure, and changes in mood.
Cushing's Disease: Silycus® Treatment Study
We are studying the effects of Silycus® on lowering cortisol levels in patients with Cushing's disease. The trial will also evaluate how well patients tolerate the treatment and its impact on their symptoms.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you at least 18 years old?
- Do you have active Cushing’s disease (a condition causing high cortisol levels)?
- Are you pregnant or breastfeeding?
- Do you have severe kidney disease or severe liver disease?
- Are you currently taking any medications for Cushing’s disease that you cannot stop?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Silycus
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dipartimento Universitario di Medicina e Chirurgia Traslazionale - UOC endocrinologia e Diabetologia
La Massimina-Casal Lumbroso, Italy
Azienda Ospedaliera Universitaria Gaetano Martino Messina
D.A.I. Scienze Mediche - UOC di Endocrinologia
Messina, Italy
Azienda Ospedaliera di Padova
Dipartimento di Medicina DIMED - Reparto di Endocrinologia
Padova, Italy
Sponsor: Istituto Biochimico Italiano Giovanni Lorenzini S.p.A.
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.