Daratumumab for Very High-Risk T-Cell Acute Lymphoblastic Leukemia

We are studying whether adding daratumumab to standard treatment helps adults with very high-risk T-ALL achieve better disease control. This trial will also assess the safety and effectiveness of this combination therapy.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Aciclovir
Aciclovir is an antiviral medicine used to treat herpes infections such as cold sores, genital herpes, and shingles.
Allopurinol
Allopurinol is a medicine that lowers uric acid to prevent and treat gout and certain kidney stones.
Amphotericin B Cheplapharm
Amphotericin B Cheplapharm is an antifungal medicine used to treat severe fungal infections affecting the whole body.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Aciclovir
Aciclovir is a substance that fights viral infections caused by herpes viruses, helping treat cold sores, genital herpes, and shingles.
Allopurinol
Allopurinol is a substance that lowers uric acid levels to prevent gout attacks and related complications.
Amphotericin B
Amphotericin B is a substance that treats serious systemic fungal infections.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

1 Year Plus Allergy Relief Antihistamine
4-In-One Flu Relief
6 Years Plus Paracetamol Boots

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
DIPARTIMENTO MALATTIE ONCOLOGICHE ED EMATOLOGICHE
Bologna, Italy
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
EMATOLOGIA
Brescia, Italy
ASST Grande Ospedale Metropolitano Niguarda
DIPARTIMENTO DI EMATOLOGIA,ONCOLOGIA E MEDICINA MOLECOLARE
Bresso, Italy

Sponsor: Fondazione Gimema Franco Mandelli Onlus
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.