Darolutamide and Bipolar Androgen Therapy for Advanced Prostate Cancer

We are studying whether combining Darolutamide with bipolar androgen therapy improves survival and quality of life for men with metastatic castration-resistant prostate cancer compared to standard treatments.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Abiraterone
Abiraterone is a medicine used to treat prostate cancer by lowering male hormones that can make the cancer grow.
Cabazitaxel
Cabazitaxel is a chemotherapy medicine used to treat advanced prostate cancer after other treatments have stopped working.
Testogel Dosiergel
Testogel Dosiergel is a topical gel applied to the skin to replace low testosterone in men.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Abiraterone
Abiraterone is a substance that reduces testosterone production to help manage advanced prostate cancer.
Abiraterone Acetate
Abiraterone acetate is a substance that lowers the body's male hormones to slow the growth of prostate cancer.
Cabazitaxel
Cabazitaxel is a chemotherapy substance used to treat advanced prostate cancer by killing rapidly dividing cells.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Bay 1841788

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abaxan
Abibam®
Abinone

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Urologicum Duisburg
Urologicum Duisburg
Dinslaken, Germany
Medical Center - University Of Freiburg
Klinik fuer Urologie
Freiburg, Germany
Universitaet Muenster
Klinik fuer Urologie und Kinderurologie
Münster, Germany

Sponsor: Universitaet Muenster
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.