Dermatomyositis and Polymyositis: PF-06823859 Study

We are testing a new medication to see if it helps reduce muscle and skin symptoms in adults with active dermatomyositis or polymyositis. This study compares the new treatment to a placebo to evaluate its effectiveness.

Confirmation phase (III)Post-Trial Drug Access Cost Reimbursement Partially Remote Investigational Medicines Oral InjectionInternal MedicineRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Budesonide

Budesonide is a medicine that reduces swelling in the lungs and airways to help people with asthma and other breathing problems.

Dazlaris

Deflazacort

Deflazacort is a steroid medicine used to reduce inflammation and treat muscle-wasting conditions such as Duchenne muscular dystrophy.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Azathioprine

Azathioprine is a substance that suppresses the immune system to prevent organ rejection and treat autoimmune diseases.

Azelastine Hydrochloride

Azelastine hydrochloride is a substance that relieves allergy symptoms like sneezing, runny nose, and itchy, watery eyes.

Betamethasone

Betamethasone is a corticosteroid substance that reduces inflammation and suppresses immune responses for conditions like eczema, allergies, and arthritis.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Dazukibart

PF-06823859

Humanised IgG1k Monoclonal Antibody Against Interferon Beta

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abix

Abriff

Acecort

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Leuven

Neurology

Heverlee, Belgium

Hopital Erasme

Neurology

Negenmanneke, Belgium

Medical Center Artmed Ltd.

Haskovo, Bulgaria

Sponsor: Pfizer Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.