Dexamethasone for Moderate to Severe Depression

We are studying whether adding dexamethasone to standard depression treatment can improve symptoms for those with moderate to severe depression. This trial aims to assess its safety and effectiveness.

6-12 months≤5 visitsConfirmation phase (III)Cost ReimbursementPartially RemoteInvestigational MedicinesOralPsychiatry

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Citalopram
Citalopram is a medication used to treat depression and certain anxiety disorders.
Escitalopram
Escitalopram is a medicine used to treat depression and certain anxiety disorders.
Mirtazapine
Mirtazapine is a medicine used to treat depression and help improve mood, sleep, and appetite.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Citalopram
Citalopram is a substance that helps improve mood and reduce symptoms of depression and anxiety.
Citalopram Hydrobromide
Citalopram hydrobromide is a substance that helps relieve depression and anxiety by increasing serotonin levels in the brain.
Dexamethasone
Dexamethasone is a steroid that reduces inflammation and suppresses the immune system to treat allergic, inflammatory, and autoimmune conditions.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Lithium

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acelopam
Aciprex
Adeprenal

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Region Hovedstadens Psykiatriske
Mental Health Center Copenhagen (MHCC)
Glostrup, Denmark
Sponsor: Region Hovedstadens Psykiatriske
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.