Diffuse Large B-Cell Lymphoma: Epcoritamab with R-CHOP

We are studying whether adding Epcoritamab to standard R-CHOP treatment helps people with newly diagnosed Diffuse Large B-Cell Lymphoma live longer without disease progression. This trial compares the new combination to R-CHOP alone.

1-2 years 6-10 visits Confirmation phase (III)No Placebo Cost Reimbursement Partially Remote Investigational Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Doxorubicinhydrochlorid Bendalis

Doxorubicinhydrochlorid Bendalis is a chemotherapy medicine used to treat various types of cancer.

Prednisone Zentiva

Prednisone Zentiva is a steroid medicine used to reduce inflammation and treat allergies, asthma, and other inflammatory conditions.

Truxima

Truxima is a medicine used to treat certain blood cancers and some autoimmune diseases by targeting and reducing harmful immune cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cyclophosphamide

Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.

Doxorubicin Hydrochloride

Doxorubicin hydrochloride is a chemotherapy substance used to treat various cancers by killing or slowing the growth of cancer cells.

Epcoritamab

Epcoritamab is a lab-made antibody that helps the immune system target and kill cancerous B cells in certain types of non-Hodgkin lymphoma.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Cyclophosphamide

Vincristine

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adriacept Blasen-Instillations-Set

Adriamycin

Adriblastin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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SCRI CCCIT Ges.m.b.H.

Department of Internal Medicine III

Salzburg, Austria

Noe LGA Gesundheit Region Mitte GmbH

Clinical Department of Internal Medicine I

Sankt Pölten, Austria

Medical University Of Vienna

Department of Hematology and Hemostaseology

Vienna, Austria

Sponsor: AbbVie Deutschland GmbH & Co. KG

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.