Diffuse Large B-Cell Lymphoma: Zilovertamab Vedotin Study

We are studying a new treatment, Zilovertamab Vedotin, combined with standard care for patients with relapsed or refractory diffuse large B-cell lymphoma. The aim is to evaluate its safety and effectiveness compared to current therapies.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Bendamustine Hydrochloride
Bendamustine Hydrochloride is a chemotherapy medicine used to treat certain blood cancers, such as chronic lymphocytic leukemia and non-Hodgkin lymphoma.
Mabthera
Mabthera is a medicine used to treat certain blood cancers and some autoimmune diseases by targeting problematic immune cells.
Ruxience
Ruxience is a medicine used to treat certain blood cancers and some autoimmune diseases.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bendamustine Hydrochloride
Bendamustine hydrochloride is a chemotherapy substance used to treat certain blood cancers by killing cancer cells.
Gemcitabine
Gemcitabine is a substance that slows or stops cancer cell growth and is used to treat several cancers, including pancreatic and lung.
Oxaliplatin
Oxaliplatin is a substance used in chemotherapy to treat colorectal and other cancers by killing cancer cells.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Zilovertamab Vedotin

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Benda Nc
Bendamedac
Bendamustin Accord

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Lyon Sud
Service d’Hématologie Clinique
Oullins, France
Assistance Publique Hopitaux De Paris
Service d’Hématologie Clinique
Salpêtrière, France
University General Hospital Of Alexandroupoli
Hematology Department
Alexandroupoli, Greece

Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.