DIPG Treatment: Targeted Drug Study for Children

We are testing how well certain drugs work for children with diffuse intrinsic pontine glioma (DIPG) based on their tumor's genetic makeup. The goal is to find safer and more effective treatments tailored to individual patients.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Rapamune
Rapamune is a medicine used to help prevent the body from rejecting a transplanted kidney by lowering the immune system’s activity.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Sirolimus
Sirolimus is a substance that suppresses the immune system to help prevent rejection after organ transplantation.
Trametinib
Trametinib is a substance that treats certain cancers by blocking cell signals that cause cancer cells to grow.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Mekinist

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Hyftor

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Górnośląskie Centrum Zdrowia Dziecka
Department of Oncology, Hematology and Chemotherapy
Mikołów, Poland
Instytut Pomnik Centrum Zdrowia Dziecka
Department of Pediatric Oncology
Wawer, Poland
Sponsor: Instytut Pomnik Centrum Zdrowia Dziecka
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.