DLBCL Treatment: Dexrazoxane for Heart Protection

We are studying whether dexrazoxane can help prevent heart problems in patients with diffuse large B-cell lymphoma receiving chemotherapy. This trial will also compare treatment responses and monitor any side effects.

3-6 months 6-10 visits Confirmation phase (III)No Placebo Standard Medicines Oral InjectionCardiologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cardioxane

Cardioxane is a medicine used to protect the heart from damage caused by certain chemotherapy drugs.

Lenalidomide

Lenalidomide is a medicine used to treat certain blood cancers and bone marrow disorders, including multiple myeloma.

Prednisolone Eg

Prednisolone Eg is a steroid medicine used to reduce swelling and treat allergies, asthma attacks, and certain immune system conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cyclophosphamide

Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.

Dexrazoxane

Dexrazoxane is a substance that helps protect the heart from damage caused by certain chemotherapy drugs.

Dexrazoxane Hydrochloride

Dexrazoxane hydrochloride is a substance that helps protect the heart from damage during certain chemotherapy treatments.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

7,5 Mg Stada

Adelcort®

Alpicort

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Jeroen Bosch Ziekenhuis

Hematology

's-Hertogenbosch, Netherlands

Ziekenhuisgroep Twente Stichting

Hematology

Almelo, Netherlands

Ziekenhuis Amstelland

Hematology

Amstelveen, Netherlands

Sponsor: Haemato Oncology Foundation For Adults Netherlands

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.